The corrosion inhibition of API 5L X60 pipeline steel in oil well acidizing fluid stimulated with 1.0 M HCl by Tranexamic Acid (TXA) was investigated using potentiodynamic polarization (PDP), electrochemical impedance spectroscopy (EIS) and the conventional gravimetric or weight loss (WL) techniques at temperatures ranging from 303 to 323 K. Surface morphological analysis was carried out us...

BACKGROUND Bleeding ulcer is a common condition, especially among the elderly population. Tranexamic acid (TXA) has been successfully used for many bleeding conditions. Its use in patients with bleeding ulcer is inclusive yet. The aim of this study was to provide an overview of the prescription of TXA. METHODS This retrospective cohort study was performed as a review of medical records at the...

BACKGROUND Tranexamic acid (TXA) has been proven to be effective in reducing blood loss and transfusion rate after total knee arthroplasty (TKA) without increasing the risk of deep vein thrombosis (DVT) and pulmonary embolism (PE). Recently, an increasing number of studies have been interested in applying combined intravenous (IV) with intraarticular (IA) tranexamic acid in total knee arthropla...

Aim: Topical Tranexamic acid (TXA) application provides maximum concentration of TXA at the bleeding site and avoids potential systemic effects. A number of blinded randomized control trials (RCT) have been published proving its safety and effectiveness. We hypothesised that in a person undergoing total knee replacement, if TXA was used topically on one side, it would reduce blood loss compared...

OBJECTIVES Antifibrinolytics are widely used in cardiac surgery to save blood perioperatively. In the present study we evaluated the hemostatic effects of tranexamic acid (TXA) to decrease bleeding tendency and transfusion requirements in high-risk patients following transapical aortic valve implantation (TA-AVI). METHODS A retrospective analysis was performed on aortic stenosis patients unde...

Tranexamic acid (TXA) is a popular antifibrinolytic drug that is commonly used in patients with bleeding disorder. Major morbidities and mortalities have been reported following inadvertent intrathecal injection of TXA. In this paper, inadvertent intrathecal injection of TXA has resulted from similarities in appearance between TXA and heavy bupivacaine 0.5% ampoules. The patient experienced sev...

BACKGROUND Adolescent idiopathic scoliosis (AIS) surgery usually require prolonged operative times with extensive soft tissue dissection and significant perioperative blood loss, and allogeneic blood products are frequently needed. Methods to reduce the requirement for transfusion would have a beneficial effect on these patients. Although many previous studies have revealed the efficacy of tran...

BACKGROUND Recently, combined intra-articular tranexamic acid (IA-TXA) injection with clamping drain method showed efficacy for blood loss and transfusion reduction in total knee replacement (TKR). However, until now, none of previous studies revealed the effect of this technique on pharmacokinetics, coagulation, and fibrinolysis. MATERIALS AND METHODS An experimental study was conducted, dur...

Ibuprofen (IBP)- and Tranexamic acid (TXA)-containing tablets are known to swell when stored at high temperatures, but the mechanism of swelling is unknown. In this study, we investigated possible with high-temperature storage. Differential scanning calorimetry (DSC) powder X-ray diffractometry (PXRD) analyses showed that a new complex was formed in swollen tablets, 50 °C for 60 days. Additiona...